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KMID : 0860920180200020077
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Journal of the Korean Association EMG-Electrodiagnostic Medicine
2018 Volume.20 No. 2 p.77 ~ p.83
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Diagnosis of Small Fiber Neuropathy: Usefulness of Skin Biopsy
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Kim Soo-Young
Sohn Eun-Hee
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Abstract
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Small fiber neuropathy (SFN) mainly affects thinly myelinated Aδ-fibers and unmyelinated C-fibers presented with neuropathic pain like burning feet or numbness. Many conditions are known as a causes of SFN, metabolic derangement, especially glucose intolerance, is the most frequent cause of SFN. It has been hard to diagnose SFN because there has been lack of specialized test for small nerve fiber. Quantification of intraepidermal nerve fiber density using skin biopsy is promising method to diagnose SFN. A skin biopsy also could give helps to research pathophysiology of SFN by specialized stain method.
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KEYWORD
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small fiber neuropathy, skin, biopsy, epidermis
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